A study published in June 2015 reports that probiotic supplementation improved triglyceride (TG) levels in individuals with hypertriglyceridemia. The Centers for Disease Control and Prevention (CDC) states that 25% of adults have elevated triglyceride levels, defined as levels greater than 150 mg/dL.
In this randomized, double-blind, placebo-controlled study, researchers assigned 128 nondiabetic subjects with hypertriglyceridemia to receive 2 grams per day of Lactobacillus curvatus and Lactobacillus plantarum or a placebo for 12 weeks. The investigators measured levels of lipids, triglycerides, and apo A-V, which is an apolipoprotein component of several lipoprotein fractions and plays a significant role in triglyceride metabolism.
Compared to baseline levels, the probiotic group had an 18.3% reduction in triglycerides, an increase of 21.1% in apo A-V, and a 15.6% increase in low-density lipoprotein (LDL) particle size, which is associated with lower risk of coronary artery disease. These changes were significant when compared to the placebo group as well.
The study authors stated, “The consumption of two probiotic strains for 12 weeks reduced TGs and increased the apo A-V and LDL particle size in hypertriglyceridemic subjects. This effect was more pronounced in subjects with higher levels of fasting TGs regardless of their APOA5 -1131T > C genotype.”
Reference: Ahn HY, et al. Atherosclerosis. 2015;241:649-56.